![]() The LR- and NL-BAV exhibited a 71% increase in peak-systolic orifice jet velocity relative to the TAV, suggesting an inherent degree of stenosis in BAVs. ![]() While all three BAVs generated skewed and asymmetrical orifice jets (up to 1.7- and 4.0-fold increase in flow angle and displacement, respectively, relative to the TAV at the sinotubular junction), the RN-BAV jet was out of the plane of observation. Phase-locked particle image velocimetry experiments were carried out to characterize the flow in the aortic root and in the tubular AA in terms of jet skewness and displacement, as well as mean velocity, viscous shear stress and Reynolds shear stress fields. Tissue BAVs reconstructed from porcine TAVs were subjected to physiologic pulsatile flow conditions in a left-heart simulator featuring a realistic aortic root and compliant aorta. The objective of this study was to compare experimentally the hemodynamics of a normal (i.e., non-dilated) ascending aorta (AA) subjected to tricuspid aortic valve (TAV), LR-BAV, RN-BAV, and NL-BAV flow. ![]() However, assessment of this theory is still hampered by the limited knowledge of the hemodynamic abnormalities generated by the distinct BAV morphotypes. The heterogeneous BAV morphotypes are associated with different dilation patterns, suggesting a role for hemodynamics in BAV aortopathogenesis. The bicuspid aortic valve (BAV) is a major risk factor for secondary aortopathy such as aortic dilation. 2Department of Mechanical and Materials Engineering, Wright State University, Dayton, OH, USA.1Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, USA.Andrew McNally 1, Ashish Madan 2 and Philippe Sucosky 2 *
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